Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways
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منابع مشابه
Relationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملActivation of presynaptic 5-hydroxytryptamine 2A receptors facilitates excitatory synaptic transmission via protein kinase C in the dorsolateral septal nucleus.
Effects of 5-hydroxytryptamine (5-HT) on EPSPs and EPSCs in the rat dorsolateral septal nucleus (DLSN) were examined in the presence of GABA(A) and GABA(B) receptor antagonists. Bath application of 5-HT (10 microm) for 5-10 min increased the amplitude of the EPSP and EPSC. (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin hydrobromide (10 microm), an agonist for 5-HT1A and 5-HT7 receptors, did not f...
متن کاملRelationship between neonatal testosterone and 5-hydroxytryptamine (5 HT) in controlling the pattern of LH release in adult rats
Relationship between neonatal testosterone and 5-hydroxytryptamine (5-HT) in controlling the pattern of LH release in adult rats was investigated in this study. Hypothalamic 5-HT concentrations are transiently lower in male as compared to female Wistar rats in the second week post-partum (pp). It has also been shown that pharmacologically potentiating 5-HT activity during this period feminizes ...
متن کاملEchinoderm microtubule-associated protein -like protein 5 in anterior temporal neocortex of patients with intractable epilepsy
Objective(s):EMAP-like Protein 5 (EML5) is a new echinoderm microtubule-associated protein that is expressed in the central nervous system. The aim of this study was to investigate the expression profile of EML5 in the anterior temporal neocortex of patients presenting with intractable epilepsy (IE). Materials and Methods:Western blot assays were performed to determine EML5 expression in 36 su...
متن کاملInhibitory presynaptic 5-hydroxytryptamine(2A) receptors regulate evoked glutamate release from rat cerebellar mossy fibers.
We studied the pharmacological characterization of the 5-hydroxytryptamine(2) (5-HT(2)) heteroreceptor located on glutamatergic cerebellar mossy fiber nerve terminals. Depolarization-evoked overflow of endogenous glutamate from rat cerebellar "giant" mossy fiber synaptosomes was inhibited by 5-HT or (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane [(+/-)-DOI], exhibiting pD(2) (= -log EC(50)...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2007
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0707377